Due to the COVID-19 pandemic the 33rd cycle ended on May 30, 2021.
Research Topics
Board of teachers:
Giovanni Sannia - Coordinator
Simonetta Bartolucci
Viola Calabro'
Rosanna Capparelli
Alberto Di Donato
Gabriella Fiorentino
Paola Giardina
Rachele Isticato
Loredana Mariniello
Antonio Marzocchella
Daria Maria Monti
Marco Moracci
Eugenio Notomista
Giuseppe Olivieri
Ermenegilda Parrilli
Francesco Pennacchio
Gennaro Piccialli
Renata Piccoli
Raffaele Porta
Rosa Rao
Piero Salatino
Maria Luisa Tutino
Thierry Tron
Angharad M. R. Gatehouse
Educational Offer reserved to PhD students of the 33rd cycle.
________________________________________________________________________________________________________________ | ||||
| PhD student | Project |
| Supervisor(s) |
| Manar Abdalrazeq | New biomaterials obtained by grafting polysaccharide/protein-based films with polyhydroxyalkanoates |
| R. Porta, G. Sannia, V. Giosafatto, C. Pezzella |
Graduated at the "An-Najah National University" | ||||
| Eleonora Barra | Use of RNAi to develop new biotechnologies for insect control |
| F. Pennacchio |
| Iolanda Corrado | Bioplastics from wastes: circular economy for a sustainable future |
| G. Sannia, C. Pezzella
|
| Nicola Curci | Identification and characterization of novel Carbohydrate Active Enzymes for (hemi)cellulose degradation by metagenomic approach of extreme environments |
| M. Moracci |
| Concetta Lauro | Geno-proteomic approaches to engineer Pseudoalteromonas haloplanktis TAC125 as a system for the production of recombinant proteins |
| M.L.Tutino, E. Parrilli |
| Roberto Natale | Systemin networks in tomato plants defense responses |
| R. Rao, M. Coppola |
| Rosanna Puopolo | Biosensors and Bioprocesses to address environmental pollution |
| G. Fiorentino |
| Felicia Sangermano | Microbial and plant bioactive metabolites for agriculture and industry |
| V. Calabrò |
________________________________________________________________________________________________________________ Dottorati industriali ________________________________________________________________________________________________________________ | ||||
| PhD student | Project |
| Supervisor |
| Angela Cesaro | Development of innovative antimicrobials for cosmeceutical applications |
| A. Arciello |
| Luigi D’elia | Microalgal biorefinery for food application: process development for intensive production and green extraction of thermo-resistant antioxidants from thermo and extremophiles strains |
| D. M. Monti |
| Rosanna Mattossovich | Development of a new enzyme-based biosensor for detection of damaged DNA, by using the thermoSNAP-display technology. |
| M. Moracci, G. Perugino |
| Giacomo Ruggiero | Optimized biofuels production by Syngas Fermentation |
| A. Marzocchella, P. Salatino |
________________________________________________________________________________________________________________ | ||||
Papers published by students of cycle XXXIII
Mattossovich R, Iacono R, Cangiano G, Cobucci-Ponzano B, Isticato R, Moracci M, Ricca E.
Conversion of xylan by recyclable spores of Bacillus subtilis displaying thermophilic enzymes.
2017, Microb Cell Fact, Vol. 16: 218.
https://doi.org/10.1186/s12934-017-0833-3
D'Elia L, Del Mondo A, Santoro M, De Natale A, Pinto G, Pollio A.
Microorganisms from harsh and extreme environments: A collection of living strains at ACUF (Naples, Italy).
2018, Ecol Quest, Vol. 29: 63-74.
https://doi.org/10.12775/EQ.2018.023
Cucciolito M E, De Luca Bossa F, Esposito R, Ferraro G, Iadonisi A, Petruk G, D'Elia L, Romanetti C, Traboni S, Tuzi A, Monti D M, Merlino A, Ruffo F.
C-glycosylation in Platinum-Based Agents: a Viable Strategy to Improve Cytotoxicity and Selectivity.
2018, Inorg Chem Front, Vol. 5: 2921-2933.
https://doi.org/10.1039/C8QI00664D
Gallo G, Puopolo R, Limauro D, Bartolucci S, Fiorentino G.
Metal-Tolerant Thermophiles: From the Analysis of Resistance Mechanisms to their Biotechnological Exploitation.
2018, Open Biochem J, Vol. 12: 149-160.
https://doi.org/10.2174/1874091X01812010149
Fontana R, Guidone D, Sangermano F, Calabrò V, Pollice A, La Mantia G, Vivo M.
PKC Dependent p14ARF Phosphorylation on Threonine 8 Drives Cell Proliferation.
2018, Sci Rep, Vol. 8: 7056.
https://doi.org/10.1038/s41598-018-25496-4
Abdalrazeq M, Giosafatto CVL, Esposito M, Fenderico M, Di Pierro P, Porta P.
Glycerol-Plasticized Films Obtained from Whey Proteins Denatured at Alkaline pH.
2019, Coatings, Vol. 9: 1-9.
https://doi.org/10.3390/coatings9050322
Gaglione R, Cesaro A, Dell'Olmo E, Della Ventura B, Casillo A, Di Girolamo R, Velotta R, Notomista E, Veldhuizen EJA, Corsaro MM, De Rosa C, Arciello A.
Effects of human antimicrobial cryptides identified in apolipoprotein B depend on specific features of bacterial strains.
2019, Sci Rep, Vol. 9: 6728.
https://doi.org/10.1038/s41598-019-43063-3
Vastano M, Corrado I, Sannia G, Solaiman DKY, Pezzella C.
Conversion of no/low value waste frying oils into biodiesel and polyhydroxyalkanoates.
2019, Sci Rep, Vol. 9: 13751.
https://doi.org/10.1038/s41598-019-50278-x
Strazzulli A, Cobucci-Ponzano B, Iacono R, Giglio R, Maurelli L, Curci N, Schiano-di-Cola C, Santangelo A, Contursi P, Lombard V, Henrissat B, Lauro F, Fontes CMGA, Moracci M.
Discovery of hyperstable carbohydrate-active enzymes through metagenomic of extreme environments.
2019, FEBS, Vol. 287: 1116–1137.
https://doi.org/10.1111/febs.15080
Curci N, Strazzulli A, De Lise F, Iacono R, Maurelli L, Dal Piaz F, Cobucci-Ponzano B, Moracci M.
Identification of a novel esterase from the thermophilic bacterium Geobacillus thermodenitrificans NG80-2.
2019, Extremophiles, Vol. 23: 407-419.
https://doi.org/10.1007/s00792-019-01093-9
Iacono R, Strazzulli A, Maurelli L, Curci N, Casillo A, Corsaro MM, Moracci M, Cobucci-Ponzano B.
Identification and characterization of GlcNAc de-N-acetylase from hyperthermophilic archaeon Sulfolobus solfataricus.
2019, App Environ Microbiol , Vol. 85: e01879-18.
https://doi.org/10.1128/AEM.01879-18
Petruk G, Monti D M, Ferraro G, Pica A, D'Elia L, Pane F, Amoresano A, Furrer J, Kowalasky K, Merlino A.
Encapsulation of the Dinuclear Trithiolato-Bridged Arene Ruthenium Complex Diruthenium-1 in an Apoferritin Nanocage: Structure and Cytotoxicity.
2019, ChemMedChem, Vol. 14: 594-602.
https://doi.org/10.1002/cmdc.201800805
Artini M, Papa R, Vrenna G, Lauro C, Ricciardelli A, Casillo A, Corsaro MM, Tutino ML, Parrilli E, Selan L.
Cold-adapted bacterial extracts as source of anti-infective and antimicrobial compounds against Staphylococcus aureus .
2019, Future Microbiol, Vol. 14: 1369-1382.
https://doi.org/10.2217/fmb-2019-0147
Del Prete S, Merlo R, Valenti A, Mattossovich R, Rossi M, Carginale V, Supuran C, Perugino G, Capasso C.
Thermostability enhancement of the α-carbonic anhydrase from Sulfurihydrogenibium yellowstonense by using the anchoring-and-self-labelling-protein-tag system (ASLtag).
2019, J Enzyme Inhib Med Chem , Vol. 34: 946-954.
https://doi.org/10.1080/14756366.2019.1605991
Lo Gullo G, Mattossovich R, Perugino G, La Teana A, Londei P, Benelli D.
Optimization of an In Vitro Transcription/Translation System Based on Sulfolobus solfataricus Cell Lysate.
2019, Archaea , Vol. 2019: ID 9848253.
https://doi.org/10.1155/2019/9848253
Merlo R, Del Prete S, Valenti A, Mattossovich R, Carginale V, Supuran CT, Capasso C, Perugino G.
An AGT-based protein-tag system for the labelling and surface immobilization of enzymes on E. coli outer membrane.
2019, J Enzyme Inhib Med Chem , Vol. 34: 490-491.
https://doi.org/10.1080/14756366.2018.1559161
Zhang Y, Natale R, Domingues AP Júnior, Toleco MR, Siemiatkowska B, Fàbregas N, Fernie AR.
Rapid Identification of Protein-Protein Interactions in Plants.
2019, Curr Protoc Plant Biol, Vol. 4: e20099.
https://doi.org/10.1002/cppb.20099
Coppola M, Lelio ID, Romanelli A, Gualtieri L, Molisso D, Ruocco M, Avitabile C, Natale R, Cascone P, Guerrieri E, Pennacchio F, Rao R.
Tomato Plants Treated with Systemin Peptide Show Enhanced Levels of Direct and Indirect Defense Associated with Increased Expression of Defense-Related Genes.
2019, Plants (Basel), Vol. 8: 395.
https://doi.org/10.3390/plants8100395
Masi M, Freda F, Sangermano F, Calabrò V, Cimmino A, Cristofaro M, Meyer S, Evidente A.
Radicinin, a Fungal Phytotoxin as a Target-Specific Bioherbicide for Invasive Buffelgrass (Cenchrus ciliaris) Control.
2019, Molecules, Vol. 24: 1086.
https://doi.org/10.3390/molecules24061086
Sangermano F, Masi M, Vivo M, Ravindra P, Cimmino A, Pollice A, Evidente A, Calabrò V.
Higginsianins A and B, two fungal diterpenoid α-pyrones with cytotoxic activity against human cancer cells.
2019, Toxicol in Vitro, Vol. 61: 104614.
https://doi.org/10.1016/j.tiv.2019.104614
Caccia S, Astarita F, Barra E, Di Lelio I, Varricchio P, Pennacchio F.
Enhancement of Bacillus thuringiensis toxicity by feeding Spodoptera littoralis larvae with bacteria expressing immune suppressive dsRNA.
2020, J Pest Sci, Vol. 93: 303-314.
https://doi.org/10.1007/s10340-019-01140-6
Rizzo D, Taddei A, Da Lio D, Nugnes F, Barra E, Stefani L, Bartolini L, Griffo RV, Spigno P, Cozzolino L, Rossi E, Garonna AP.
Identification of the Red-Necked Longhorn Beetle Aromia bungii (Faldermann, 1835) (Coleoptera: Cerambycidae) with Real-Time PCR on Frass.
2020, Sustainability, Vol. 12: 6041.
https://doi.org/10.3390/su12156041
Gaglione R, Cesaro A, Dell’Olmo E, Di Girolamo R, Tartaglione L, Pizzo E, Arciello A .
Cryptides identified in human Apolipoprotein B as new weapons to fight antibiotic resistance in cystic fibrosis disease.
2020, Int J Mol Sci, Vol. 21: 2049.
https://doi.org/10.3390/ijms21062049
Iacono R, Cobucci-Ponzano, De Lise, Curci N, Maurelli L, Moracci M, Strazzulli A.
Spazial metagenomic of three geothermal sites in Pisciarelli Hot Spring focusing on the biochemical resources of microbial consortia.
2020, Molecules, Vol. 25: 4023.
https://doi.org/10.3390/molecules25174023
Imbimbo P, Bueno M, D'Elia L, Pollio A, Ibanez E, Olivieri G, Monti DM,.
Green Compressed Fluid Technologies To Extract Antioxidants and Lipids from Galdieria phlegrea in a Biorefinery Approach.
2020, ACS Sustainable Chem Eng, Vol. 8: 2939-2947.
https://doi.org/10.1021/acssuschemeng.9b07505
Barone R, De Napoli L, Mayol L, Paolucci M, Maria G, D'Elia L, Pollio A, Guida M, Gambino E, Carraturo F, Marra R, Vinale F, Woo S, Lorito M.
Autotrophic and Heterotrophic Growth Conditions Modify Biomolecole Production in the Microalga Galdieria sulphuraria (Cyanidiophyceae, Rhodophyta).
2020, Mar Drugs, Vol. 18: 169.
https://doi.org/10.3390/md18030169
Tresin F, Stoppa V, Baron M, Biffis A, Annunziata A, D'Elia L, Monti D M, Ruffo F, Roverso M, Sgarbossa P, Bogialli S, Tubaro C.
Synthesis and Biological Studies on Dinuclear Gold(I) Complexes with Di-(N-Heterocyclic Carbene) Ligands Functionalized with Carbohydrates.
2020, Molecules, Vol. 25: 3850.
https://doi.org/10.3390/molecules25173850
Imbimbo P, D'Elia L, Liberti D, Olivieri G, Monti D M.
Towards green extraction methods from microalgae learning from the classics.
2020, Appl Microbiol Biotechnol, Vol. 104: 9067–9077.
https://doi.org/10.1007/s00253-020-10839-x
Rezq S, Alsemhe A, D'Elia L, El Sahlzy A, Monti D M, Sobhe M, Mahmoud M F.
Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats.
2020, Sci Rep, Vol. 10: 20559.
https://doi.org/10.1038/s41598-020-77424-0
Colarusso A, Lauro C, Calvanese M, Parrilli E, Tutino ML.
Improvement of Pseudoalteromonas haloplanktis TAC125 as a Cell Factory: IPTG-Inducible Plasmid Construction and Strain Engineering.
2020, Microorganisms, Vol. 8: 1466.
https://doi.org/10.3390/microorganisms8101466
Mattossovich R, Merlo R, Fontana A, D'Ippolito G, Terns M, Watts E, Valenti A, Perugino G.
A journey down to hell: new thermostable protein-tags for biotechnology at high temperatures.
2020, Extremophiles , Vol. 24: 81-91.
https://doi.org/10.1007/s00792-019-01134-3
Mattossovich R, Merlo R, Miggiano R, Valenti A, Perugino G.
O6-alkylguanine-DNA Alkyltransferases in Microbes Living on the Edge: From Stability to Applicability.
2020, Int J Mol Sci, Vol. 21: 2878.
https://doi.org/10.3390/ijms21082878
Merlo R, Caprioglio D, Cillo M, Valenti A, Mattossovich A, Morrone C, Massarotti A, Rossi F, Miggiano R, Leonardi A, Minassi A, Perugino G.
The SNAP-tag technology revised: an effective chemo-enzymatic approach by using a universal azide-based substrate.
2020, J Enzyme Inhib Med Chem , Vol. 36: 85-97.
https://doi.org/10.1080/14756366.2020.1841182
Molisso D, Coppola M, Aprile AM, Avitabile C, Natale R, Romanelli A, Chiaiese P, Rao R.
Colonization of Solanum melongena and Vitis vinifera Plants by Botrytis cinerea Is Strongly Reduced by the Exogenous Application of Tomato Systemin.
2020, J Fungi (Basel), Vol. 7: 15.
https://doi.org/10.3390/jof7010015
Puopolo R, Gallo G, Mormone A, Limauro D, Contursi P, Piochi M, Bartolucci S, Fiorentino G.
Identification of a New Heavy-Metal-Resistant Strain of Geobacillus stearothermophilus Isolated from a Hydrothermally Active Volcanic Area in Southern Italy.
2020, Int J Environ Res Public Health, Vol. 17: 2678.
https://doi.org/10.3390/ijerph17082678
Lanzillo F, Ruggiero G, Raganati F, Russo ME, Marzocchella A.
Batch Syngas fermentation by Clostridium carboxidivorans for production of acids and alcohols.
2020, Processes, Vol. 8: 1075.
https://doi.org/10.3390/pr8091075
Zatout R, Masi M, Sangermano F, Vurro M, Zonno MC, Santoro E, Calabrò V, Superchi S, Evidente A.
Drophiobiolins A and B, Bioactive Ophiobolan Sestertepenoids Produced by Dreschslera gigantea.
2020, J Nat Prod, Vol. 83: 3387-3396.
https://doi.org/10.1021/acs.jnatprod.0c00836
Sangermano F, Delicato A, Calabrò V.
Y box binding protein 1 (YB-1) oncoprotein at the hub of DNA proliferation, damage and cancer progression.
2020, Biochimie, Vol. 179: 205-216.
https://doi.org/10.1016/j.biochi.2020.10.004
Corrado I, Abdalrazeq M, Pezzella C, Di Girolamo R, Porta R, Sannia G, Giosafatto CVL.
Design and characterization of poly (3-hydroxybutyrate-co-hydroxyhexanoate) nanoparticles and their grafting in whey protein-based nanocomposites.
2021, Food Hydrocoll, Vol. 110: 106167.
https://doi.org/10.1016/j.foodhyd.2020.106167
Dell’Olmo E, Gaglione R, Cesaro A, Cafaro V, Teertstra WR, de Cock H, Notomista E, Haagsman HP, Veldhuizen EJA, Arciello A .
Host Defence Peptides identified in human Apolipoprotein B as promising antifungal agents.
2021, Appl Microbiol Biotechnol, Vol. 105: 1953-1964.
https://doi.org/10.1007/s00253-021-11114-3
Turco R, Santagata G, Corrado I, Pezzella C, Di Serio M.
In vivo and Post-synthesis Strategies to Enhance the Properties of PHB-Based Materials: A Review.
2021, Front Bioeng Biotechnol, Vol. 8: 619266.
https://doi.org/10.3389/fbioe.2020.619266
Corrado I, Cascelli N, Ntasi G, Birolo L, Sannia G, Pezzella C.
Optimization of Inulin Hydrolysis by Penicillium lanosocoeruleum Inulinases and Efficient Conversion Into Polyhydroxyalkanoates.
2021, Front Bioeng Biotechnol, Vol. 9: 616908.
https://doi.org/10.3389/fbioe.2021.616908
Corrado I, Vastano M, Cascelli N, Sannia G, Pezzella C.
Turning Wastes into Resources: Exploiting Microbial Potential for the Conversion of Food Wastes into Polyhydroxyalkanoates.
2021, Bio-valorization of waste. Ed. Springer Singapore. pp. 133-168.
https://doi.org/10.1007/978-981-15-9696-4_6
Farag N, Mattossovich R, Merlo R, Nierzwick L, Palermo G, Porchetta A, Perugino G, Ricci F .
Folding-upon-Repair DNA Nanoswitches for Monitoring the Activity of DNA Repair Enzymes.
2021, Angew Chem Int Ed, Vol. 60: 2-9.
https://doi.org/10.1002/anie.202016223
Puopolo R, Sorrentino I, Gallo G, Piscitelli A, Giardina P, Le Goff A, Fiorentino G.
Self-assembling thermostable chimeras as new platform for arsenic biosensing.
2021, Sci Rep, Vol. 11: 2991.
https://doi.org/10.1038/s41598-021-82648-9
Aulitto M, Gallo G, Puopolo R, Mormone A, Limauro D, Contursi P, Piochi M, Bartolucci S, Fiorentino G.
Genomic Insight of Alicyclobacillus mali FL18 Isolated From an Arsenic-Rich Hot Spring.
2021, Front Microbiol, Vol. 12: 639697.
https://doi.org/10.3389/fmicb.2021.639697
Gallo G, Puopolo R, Carbonaro M, Maresca E, Fiorentino G.
Extremophiles, a Nifty Tool to Face Environmental Pollution: From Exploitation of Metabolism to Genome Engineering.
2021, Int J Environ Res Public Health, Vol. 18: 5228.
https://doi.org/10.3390/ijerph18105228
Corrado I, Petrillo C, Isticato R, Casillo A, Corsaro MM, Sannia G, Pezzella C.
The power of two: An artificial microbial consortium for the conversion of inulin into Polyhydroxyalkanoates.
2021, Int J Biol Macromol, Vol. 189: 494-502.
https://doi.org/10.1016/j.ijbiomac.2021.08.123
D'Elia L, Imbimbo P, Liberti D, Bolinesi F, Pollio A, Mangoni O, Brilman W, Olivieri G, Monti D M.
Switchable Solvent Selective Extraction of Hydrophobic Antioxidants from Synechococcus bigranulatus.
2021, ACS Sustainable Chem. Eng., Vol. 9: 13798–13806.
https://doi.org/10.1021/acssuschemeng.1c04400
D’Elia L, Imbimbo P, Liberti D, Olivieri G, Pollio A, Monti D M .
Thermo resistant antioxidants from photoautotrophic microorganisms: screening and characterization.
2021, WIBI, Vol. 37: 1-13.
https://doi.org/doi.org/10.1007/s11274-021-03180-6
